November 10, 2011
NEW YORK, Nov. 10 — Dell today announced a major commitment of funding, employee engagement and cloud computing technology to support pediatric cancer research programs globally, including the world's first personalized medicine trial for pediatric cancer conducted by the Neuroblastoma and Medulloblastoma Translational Research Consortium (NMTRC) and supported by The Translational Genomics Research Institute (TGen). TGen will use its genomic technology within Dell's donated cloud to help NMTRC identify a greater depth of personalized treatment strategies for children with neuroblastoma who are enrolled in NMTRC's clinical trial.
Dell is expanding its Powering the Possible program to focus on neuroblastoma and other pediatric cancers because of the devastating nature of the disease and to address the void of new and innovative treatments available for children. Since the 1980s, the Food and Drug Administration (FDA) has approved only one new treatment for any type of childhood cancer, compared with 50 approved treatments for adult cancers in the same time period. Through Powering the Possible, Dell is making a multi-year, multi-million dollar commitment of funds and employee volunteerism to support innovative pediatric treatment programs globally.
"Trial and Error" treatment ineffective and time consuming
Neuroblastoma strikes one in 100,000 children annually, usually before the age of 5, and despite it being so rare, it is so deadly that it is responsible for one in seven pediatric cancer deaths. It attacks the sympathetic nervous system, which controls heart rate, blood pressure and digestion, with aggressive tumors that are unique to each child. In fact, it is the unique and aggressive nature of neuroblastoma tumors that render ineffective conventional approaches to developing a blockbuster, one-size-fits-all treatment to the disease. With little commercially or federally funded research underway because of its small patient base, parents and pediatric oncologists have relied largely on "trial and error" in their search for a treatment that will work from among the hundreds of available adult cancer trials.
Genomic guided treatment underway
To overcome these challenges, parents and physicians and scientists from the NMTRC, the Van Andel Research Institute (VARI) and TGen have teamed to launch the world's first personalized medicine clinical trial investigation for pediatric cancer. The trial, funded primarily by parents of children with neuroblastoma and their foundations, is based on research from a group of collaborating investigators who are developing a personalized medicine process that is intended to permit near "real time" processing of information on patient tumors and prediction of best drugs for a specific patient.
This process generates more than 200 billion measurements per patient that must be analyzed, shared and stored. Unfortunately, the computation and analysis of this information can take weeks to months to process and the magnitude of this task has limited the depth and number of pediatric cancer patients who can be included in this groundbreaking clinical trial.
Dell-donated cloud gives TGen and NMTRC power to do more for pediatric cancer
Dell's donated cloud solution will provide needed computing power to help increase TGen's gene sequencing and analysis capacity by 1,200 percent1 and improve collaboration between the team of physicians, genetic researchers, pharmacists and computer scientists working on the trial. Specifically, scientists and physicians will use the donated cloud to investigate new technologies that accelerate genetic analysis and identification of targeted treatments for each patient from months to days. The additional computing power will also improve the availability of critical information and allow researchers to develop a real-time knowledge repository of the latest findings on the most effective treatments for oncologists to use globally. The researchers also intend to use the donated cloud to expand the program's participation from a handful of children today to hundreds of children over the next three years, with the goal of establishing an information framework that, subject to regulatory approval, could one day help thousands of pediatric cancer patients. The new TGen cloud will also facilitate rapid transfer of information to international partners and lay the groundwork for expansion of the trial to additional types of childhood cancers in the future.
NMTRC Hospitals now enrolling patients
NMTRC is now enrolling patients in the first stages of this personalized medicine trial. Participating medical centers include:
"Even at this earliest moment in genomics-guided therapy, there is universal recognition that the amount and complexity of data is overwhelming," said Jeffrey M. Trent, Ph.D., president and research director of TGen and VARI. "Dell's commitment to helping children with cancer, coupled with its expertise in developing cloud-based solutions for health information, will provide great benefit in terms of helping us manage the massively complex data generated by this clinical trial. This will help physicians and scientists share information rapidly, and is designed to help us arrive at the optimal treatment decision for each child battling cancer."
"This trial offers hope to those children facing what is among the worst of all pediatric cancers," said Giselle Sholler, M.D., NMTRC chair and co-director of VARI's Pediatric Cancer Translational Research Program. "We are confident the genomic-based personalized medicine approach is the right one, and Dell's contribution will help remove barriers that currently exist in how rapidly and easily we can analyze and share information to benefit our patients."
"For far too long, children with pediatric cancer have relied on the hand-me-down adult cancer treatments which are brutally harsh and, in many cases, more punitive than curative for children. We've given them to kids because something is better than nothing," said Patrick Lacey, co-founder and president of Friends of Will Cancer Foundation. "And now, thanks to innovative doctors and Dell's incredible support, kids will finally get a chance at treatment designed to improve their lives and survival. They don't have to settle for brutal and ineffective therapy as status quo any longer and they have a chance to trail blaze the way to more effective and less toxic therapy for everyone with cancer."
"I applaud Dell's commitment toward filling a great void in the development of specialized treatments for childhood cancers. Childhood cancer is the leading disease killer of American children. Because of the orphan nature of these diseases and the high cost of drug development for them, it's been difficult for the pharmaceutical industry to develop treatments," said Congressman Michael McCaul (R-Texas), founder and co-chair of the Congressional Childhood Cancer Caucus, who recently introduced legislation to incentivize the pharmaceutical industry to develop such treatments. "This is the kind of private endeavor that is needed to save and improve the lives of so many children."
"It's time to do more for the children and families battling pediatric cancer," said Paul Bell, president of Dell Public and Large Enterprise and chairman of Dell's Strategic Giving Council. "And pediatric cancer is an area where Dell can address an unmet medical need and our people and technology can make an immediate and lasting difference. We hope TGen's new cloud will help pediatric oncologists develop new ways to eliminate the trial and error in the treatment for pediatric cancer patients for whom every day matters."
Dell Inc. (NASDAQ: DELL) listens to customers and delivers innovative technology and services that give them the power to do more. Dell's Powering the Possible program is funded by the company's pledge to contribute 1 percent of its pre-tax profits to learning, pediatric cancer, innovative social entrepreneurship and disaster relief initiatives that address unmet needs globally and enable human potential. Information about Dell Powering the Possible is available at www.dell.com/pediactriccancer. As the leading provider of healthcare IT services in the world, Dell helps healthcare organizations harness the power of information to simplify administration; coordinate and manage patient care; transition from episodic care to prevention and wellness management and ultimately to deliver personalized medicine.
The Translational Genomics Research Institute (TGen) is a Phoenix, Arizona-based non-profit organization dedicated to conducting groundbreaking research for life changing results. Research at TGen is focused on helping patients with diseases such as cancer, neurological disorders and diabetes. TGen is on the cutting edge of translational research where investigators are able to unravel the genetic components of common and complex diseases. Working with collaborators in the scientific and medical communities, TGen believes it can make a substantial contribution to the efficiency and effectiveness of the translational process. TGen is affiliated with the Van Andel Research Institute in Grand Rapids, Michigan. For more information, visit: www.tgen.org.
About the Neuroblastoma and Medulloblastoma Translational Research Consortium
Founded in 2008, the NMTRC is a nationwide network of childhood cancer trials based at the Van Andel Research Institute and chaired by Dr. Giselle Sholler. The consortium includes the following clinical partners: Cardinal Glennon Children's Medical Center, Saint Louis University School of Medicine; Center for Children's Cancer and Blood Disorders at Arnold Palmer Hospital for Children, MD Anderson Cancer Center Orlando; Children's Mercy Hospitals and Clinics; Connecticut Children's Medical Center; Doernbecher Children's Hospital, Oregon Health & Science University; Helen DeVos Children's Hospital; Levine Children's Hospital; Medical University of South Carolina; National Cancer Institute; Rady Children's Hospital San Diego, UCSD School of Medicine and the University of Hawaii Cancer Center.
1. Compared with TGen's existing Clinical Cluster
Source: Dell, Inc.
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